The secret conversation between your brain and gut

All of us have been there. We prepare to head into a meeting. Our hands get sweaty. Our minds race. Something doesn’t feel right; something feels off. And in that moment, we make a snap decision.

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I followed my gut.

That’s what we tell ourselves. These gut instincts can have major consequences, from trivial everyday decisions to major lifestyle choices like choosing our dream home or picking our spouse after love-at-first sight.

The term “gut instinct” may once have seemed like a cliché, but a plethora of scientific research has shown there is indeed a connection — that more information passes between our brains and our guts than any other systems in our bodies.

While people often use phrases like “trust your gut” or “going with my gut,” scientists generally draw a distinction between intuitive decision-making and the biological gut-brain link. Research has established that the gut and brain communicate — which can influence emotions and cognition — yet there is little scientific evidence to support that sensations arising from the gut provide a reliable basis for making better decisions.

Researchers also point out that emotions don’t originate in the gut itself; rather they begin in the brain. That said, the gut-brain connection is wired in fascinating ways, with a constant two-way flow of information.

“Yes, it’s true that there is a significant exchange of information between the gut and the brain — and the gut-brain axis is one of the most actively communicating systems in the body,” says Julia Zumpano, a registered dietician and nutritionist with the Cleveland Clinic.

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In fact, your gut contains what is often called your “second brain,” known as the enteric nervous system, made up of more than 500 million neurons. It is the most complex neural network outside of your brain, working with your nervous system and gathering information that is sent back to your brain, according to the Cleveland Clinic.

Messenger systems and emotions

There is a “bi-directional relationship” between your gut and brain. Your vagus nerve serves as a main conduit for the body’s inflammatory immune response to disease, bacteria and viruses, and it sends signals back and forth between your brain, gut and other internal organs.

These messenger systems can affect everything from hunger and urgency to nausea and pain. They also can “influence processes relevant to affect emotion and cognition,” says Zumpano. Sleep, cognition, metabolism, immune function, and mood and mental health are all affected.

“There have been studies that prove the gut-brain connection,” Zumpano says.

It’s important to note that just because you have a gut feeling about something, it doesn’t mean it’s right. Overspend on your dream home, and you can end up bankrupt. Follow your gut in love and, like a Shakespearean tragedy, you can end up with a broken heart.

There is a “bi-directional relationship” between your gut and brain with the vagus nerve serving as a main conduit. Signals travel back and forth along the nerve and through the bloodstream that can affect everything from hunger and urgency to nausea and pain.
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Feelings ‘do not originate in the gut’

Peter Holzer, a neuroscientist at the Medical University of Graz in Austria, penned a 2022 paper called “Gut Signals and Gut Feelings: Science at the Interface of Data and Beliefs.”

He said the signals between the gut and brain are so interconnected that the gut-brain axis “enables the brain to ‘know’ the internal state of the body.”

“Functional imaging studies have shown that information coming from the gut reaches brain regions relevant to emotion, affect (mood) and cognition,” Holzer wrote. “The complex gut-brain-gut communication network contributes to interoception, a process that integrates information from all internal organs to impact various domains of brain activity and behavior.”

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If anything, Holzer took issue with the term “gut instinct,” as an oversimplification. Despite the intrinsic gut-brain connections, he emphasized, “Feelings or emotions do not originate in the gut but are generated in the brain.”

Dr. Emeran Mayer, a renowned gastroenterologist and neuroscientist at the University of California, Los Angeles, changed the entire conversation more than a decade ago with a landmark review paper in the journal Nature Reviews Neuroscience.

“The concept that the gut and the brain are closely connected, and that this interaction plays an important part not only in gastrointestinal function but also in certain feeling states and in intuitive decision making, is deeply rooted in our language,” Mayer wrote at the time.

He has since pioneered the field, writing bestsellers like “The Mind-Gut Connection” and churning out more research explaining its effects on conditions as far ranging as Alzheimer’s to depression.

Improving gut health remains important

While the research continues to break new ground, traditional Chinese medicine and other Asian traditions have long placed an emphasis on the mind and body connection, dating back thousands of years.

“Growing evidence indicates that gut microbiota can influence the onset and progression of multi-organ system diseases through their effects on the gut-organ axis,” wrote lead Chinese researcher Tingting Luo in a 2024 research paper. “Traditional Chinese medicine has demonstrated significant efficacy in regulating the gastrointestinal system, leveraging its unique advantages.”

No matter where you live or what your traditions might be, there are multiple things you can do improve your gut-brain connection, according to Zumpano with the Cleveland Clinic.

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This includes: a varied plant heavy diet; fiber rich foods such as nuts, seeds legumes, fruits, vegetables and whole grains; fermented foods such as miso, kimchi, natto, sauerkraut, yogurt and kefir; pre-biotic foods; and foods with Omega 3 fats like salmon, tuna and mackerel.

In addition, Zumpano says to cut down on sugar and highly processed foods and stay hydrated, preferably with water.

“Improving the gut-brain connection focuses on improving gut health, supporting the helpful gut bacteria, and reducing inflammation,” she says.

There’s no quick fix, Zumpano says, but making changes to your diet will show benefit in the long run.

She adds that the “gut-brain axis is one of the most actively communicating systems in the body,” so it’s important that the connection remain healthy, especially since “the vast number of neurons and chemical messengers involved in gut-brain communication is unmatched.”

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