{"id":576,"date":"2026-05-26T09:34:39","date_gmt":"2026-05-26T09:34:39","guid":{"rendered":"https:\/\/relocationtimess.com\/?p=576"},"modified":"2026-05-26T09:34:39","modified_gmt":"2026-05-26T09:34:39","slug":"antidepressants-and-pregnancy-what-parents-to-be-should-know-about-adhd-autism-risks","status":"publish","type":"post","link":"https:\/\/relocationtimess.com\/?p=576","title":{"rendered":"Antidepressants and pregnancy: What parents-to-be should know about ADHD, autism risks"},"content":{"rendered":"
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\n Concerns about whether antidepressantscause harms to developing fetuses, including neurodevelopmental disorders, have grown in recent years.\n <\/p>

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\n Now, a group of researchers has published the best evidence to date on links between both parents\u2019 antidepressant use before and during pregnancy, and autism and attention deficit hyperactivity disorder in their children. The large study found thatfor most antidepressants, exposure during either period ultimately had little to no association with the conditions once the authors considered other influential factors.\n <\/p>\n

\n The evidence results from a review and meta-analysis of 37 previous studies including more than 600,000 pregnant women taking antidepressants, and nearly 25 million pregnancies with no antidepressant use. The report was published Thursday in the journal The Lancet Psychiatry.\n <\/p>\n

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\n Initially, the authors found maternal antidepressant use during pregnancy was linked with a 35% higher risk of ADHD and a 69% higher risk of autism without intellectual disabilities. Use of the medications by the father was associated with a 46% higher risk of ADHD and a 28% increase in the risk of autism. However, when the researchers adjusted the findings for other factors that can affect risk for the conditions, known as confounders \u2014 such as genetic and familial influences and the reasons for taking antidepressants \u2014 most links significantly weakened or disappeared. The risk for autism decreased to about 15%.\n <\/p>\n

\n \u201cThis pattern strongly suggests that the higher rates of ADHD and autism seen in previously exposed groups are largely driven by the underlying vulnerability of these mothers and families,\u201d said Dr. Wing Chung Chang , co-senior author of the study and clinical professor of psychiatry at the University of Hong Kong, via email.\n <\/p>\n

\n Antidepressants \u201care the mainstay medication treatment for depressive disorder,\u201d which affects more than 10% of pregnant women worldwide, Chang added. Much of the conversation around potential risks has centered on selective-serotonin reuptake inhibitors, which are known as SSRIs and are the most prescribed class of antidepressants.\n <\/p>\n

\n \u201cThis concern has been amplified by the July 2025 FDA expert panel discussions about possibly strengthening warnings on SSRIs in pregnancy, highlighting potential risks such as autism, miscarriage, and birth defects,\u201d Chang said. Medical organizations made during the event held by the US Food and Drug Administration for being \u201calarmingly unbalanced\u201d and neglecting to \u201cadequately acknowledge the harms of untreated perinatal mood disorders.\u201d\n <\/p>\n

\n Past studies have amounted to an inconsistent body of evidence and have been limited by small sample sizes and insufficient measurement of confounders, Chang said. Additionally, until now, no reviews have comprehensively evaluated the potential effects of the antidepressant class, specific antidepressant,medication dose, and both maternal and paternal antidepressant use shortly before or during pregnancy, he added. These gaps \u2014 as well as the significant positives of antidepressants and the risks of untreated depression \u2014 steered the authors\u2019 research.\n <\/p>\n

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\nUS Health and Human Services Secretary Robert F. Kennedy Jr. says he\u2019s looking into the effects of antidepressants.<\/span>\n<\/div>\n
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\n They also wanted \u201cto help clinicians and patients make informed choices,\u201d Chang added.\n <\/p>\n

\n Making treatment decisions\n<\/h2>\n

\n Experts understand that the potential impact of psychiatric medications on children \u201cis naturally a source of concern for parents and prescribing clinicians alike,\u201dsaid Dr. Jonathan Alpert, the Dorothy and Marty Silverman Chair of the department of psychiatry and behavioral sciences at Montefiore Medical Center in New York City, via email.\n <\/p>\n

\n \u201cPregnancy is inevitably a time of heightened worry about one\u2019s health and the health of one\u2019s unborn child,\u201d added Alpert, who wasn\u2019t involved in the study.\n <\/p>\n

\n People planning to have kids or those who are already pregnant should know that the study\u2019s findings affirm current clinical guidelines, which generally support continuing antidepressant treatment during pregnancy when needed, Chang said. \u201cOur findings do not provide strong evidence that prenatal antidepressant exposure causes neurodevelopmental disorders.\u201d\n <\/p>\n

\n When there is concern, patients and clinicians should have in-depth discussions that include weighing \u201cthe potential small risks of continued medication against the substantial risks of untreated maternal depression and make a carefully considered, individualized decision,\u201d Chang said.\n <\/p>\n

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\nExperts explain why the possibility of withdrawal when quitting antidepressants doesn’t mean the medications are addictive.<\/span>\n<\/div>\n
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\n In addition to impacts of untreated depression on the mother, developing children are also at greater risk for prematurity and low birth weight, and higher rates of impulsivity, socialization issues, and cognitive, behavioral and emotional difficulties. Perinatal mental health issues can lead to altered metabolism of serotonin, placental dysfunction and inflammation, and altered fetal brain structure, said Dr. Nancy Byatt, a perinatal psychiatrist, via email.\n <\/p>\n

\n Mental health conditions also caused nearly 28%<\/strong> of maternal pregnancy-related deaths in 2022, up from 23% in 2017 to 2019, Byatt added. Byattwasn\u2019t involved in the study and is also executive director of the Lifeline for Families Center and Lifeline for Moms Program and a professor at UMass Chan Medical School.\n <\/p>

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\n If the decision is to stop taking antidepressants, that should only be done gradually with close clinical monitoring and while practicing other ways to get or stay well, Alpert said. Antidepressant discontinuation syndrome can be particularly distressing in combination with common pregnancy symptoms such as nausea and fatigue, Chang said.\n <\/p>\n

\n \u201cPlease appreciate that you are supporting good health for both of you by getting the treatment you need,\u201d Alpert said.\n <\/p>\n

\n Depending on how severe your depression is, nonpharmaceutical treatments such as different therapies may help, the authors said.\n <\/p>\n

\n Given the findings, the mental health of the fathers \u201cmight also represent a key, yet understudied, contributor to offspring neurodevelopmental risk,\u201d the researchers wrote in the study. \u201cPerinatal psychiatry has evolved into a field of three, involving mother, infant, and father. Optimising both maternal and paternal mental health is essential, not only for the parents\u2019 own wellbeing, but also for the child\u2019s long-term development.\u201d\n <\/p>\n

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\n \u2018Meaningful reassurance\u2019 about antidepressant safety\n<\/h2>\n

\n In the new research, involving parents around age 28 on average, antidepressant use was largely not associated with increased risks of motor disorders, speech and language disorders, and intellectual disabilities.\n <\/p>\n

\n Minimally increased risks for ADHD and autism also didn\u2019t seem to depend on antidepressant dosage, but most studies included in the review didn\u2019t have detailed information on dosing, Chang said. \u201cThis is a particularly relevant question in pregnancy, where doses are sometimes increased to account for changes in plasma volume and drug metabolism.\u201d\n<\/p>\n

\n Similarly, only a few studies examined potential influences of the length of treatment or other more detailed exposure patterns, so the authors of the latest research couldn\u2019t reliably tell possible differences between continuous antidepressant use or use that was limited to one trimester, for example, Chang said. Since the fetal brain and nervous system develop throughout pregnancy, clarifying these factors is an important next step, he added.\n <\/p>\n

\n Overall, the findings, \u201ctogether with a growing body of rigorous science on the topic of antidepressant use during pregnancy, offer meaningful reassurance about safety of contemporary antidepressants,\u201d Alpert said.\n <\/p>\n

\n What\u2019s more concerning are the results for tricyclic antidepressants, which are older as they were first discovered in the 1950s and \u201960s, Alpert said \u2014 the first SSRI, fluoxetine, was developed in the 1970s and approved for the US by the FDA in 1987. While SSRIs affect only the neurotransmitter serotonin, tricyclic antidepressants such as amitriptyline and nortriptyline impact both serotonin and norepinephrine and other chemical messengers. These drugs therefore have more negative side effects and are considered second- or third-line treatments.\n <\/p>\n

\n In the new research, when other influential factors were considered, only amitriptyline and nortriptyline remained linked with a higher risk of ADHD.\n <\/p>\n

\n \u201cWhether that link is causal \u2026 or whether it is due to other factors, such as the greater severity of depression for which this class of older antidepressants is often reserved, remains unknown,\u201d Alpert said. \u201cPending further research on this topic, it is worthwhile for pregnant individuals on these older medications or considering starting them to discuss the potential risks and benefits with their clinicians.\u201d\n<\/p>\n

\n For any health and medication concerns during pregnancy, seeking guidance from trusted sources is important, Alpert said. Besides perinatal health clinicians, he added, those sources can include the American College of Obstetricians and Gynecologists, the American Academy of Pediatrics, and the American Psychiatric Association.\n <\/p>\n

\n

Clarification: This story has been updated with more detail on the prevalence of pregnancy-related deaths caused by mental health conditions.<\/p>\n<\/div>\n

\n Get inspired by a weekly roundup on living well, made simple. Sign up for CNN\u2019s Life, But Better newsletter for information and tools designed to improve your well-being.\n<\/p>

Read more \u2018The patient is a VIP\u2019: Inside Jeffrey Epstein\u2019s close ties to Mount Sinai Hospital<\/a><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

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